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The precursor of resolvin D series and aspirin‐triggered resolvin D1 display anti‐hyperalgesic properties in adjuvant‐induced arthritis in rats
Author(s) -
LimaGarcia JF,
Dutra RC,
da Silva KABS,
Motta EM,
Campos MM,
Calixto JB
Publication year - 2011
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01345.x
Subject(s) - hyperalgesia , inflammation , arthritis , freund's adjuvant , pharmacology , medicine , aspirin , docosahexaenoic acid , lipid signaling , chemistry , immunology , endocrinology , receptor , nociception , polyunsaturated fatty acid , biochemistry , fatty acid
Resolution of inflammation is mediated by endogenous molecules with anti-inflammatory and pro-resolving activities and they have generated new possibilities for the treatment of inflammatory diseases. Here, we have investigated the possible anti-hyperalgesic effects of two lipids, aspirin-triggered resolvin D1 (AT-RvD1) and its precursor, 17(R)-hydroxy-4Z,7Z,10Z,13Z,15E,17R,19Z-docosahexaenoic acid (17(R)HDoHE).