Premium
Activation of vascular KCNQ (K v 7) potassium channels reverses spasmogen‐induced constrictor responses in rat basilar artery
Author(s) -
Mani Bharath K,
Brueggemann Lioubov I,
Cribbs Leanne L,
Byron Kenneth L
Publication year - 2011
Publication title -
british journal of pharmacology
Language(s) - Slovenian
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01273.x
Subject(s) - basilar artery , electrical impedance myography , myocyte , potassium channel , channel blocker , nimodipine , medicine , pharmacology , chemistry , cardiology , endocrinology , vasodilation , calcium
Cerebral vasospasm is the persistent constriction of large conduit arteries in the base of the brain. This pathologically sustained contraction of the arterial myocytes has been attributed to locally elevated concentrations of vasoconstrictor agonists (spasmogens). We assessed the presence and function of KCNQ (K(v) 7) potassium channels in rat basilar artery myocytes, and determined the efficacy of K(v) 7 channel activators in relieving spasmogen-induced basilar artery constriction.