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Does airway smooth muscle express an inflammatory phenotype in asthma?
Author(s) -
Damera Gautam,
Panettieri, Jr Reynold A
Publication year - 2011
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2010.01165.x
Subject(s) - paracrine signalling , autocrine signalling , phenotype , airway hyperresponsiveness , inflammation , medicine , asthma , airway , immunology , neuroscience , bioinformatics , biology , receptor , anesthesia , gene , biochemistry
In addition to hyperresponsiveness in asthma, airway smooth muscle (ASM) also manifests an inflammatory phenotype characterized by augmented expression of mediators that enhance inflammation, contribute to tissue remodelling and augment leucocyte trafficking and activity. Our present review summarizes contemporary understanding of ASM-derived mediators and their paracrine and autocrine actions in airway diseases.