Premium
Co‐operative signalling through DP 1 and DP 2 prostanoid receptors is required to enhance leukotriene C 4 synthesis induced by prostaglandin D 2 in eosinophils
Author(s) -
MesquitaSantos FP,
BakkerAbreu I,
LunaGomes T,
Bozza PT,
Diaz BL,
BandeiraMelo C
Publication year - 2011
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2010.01086.x
Subject(s) - lipid signaling , receptor , chemistry , pertussis toxin , eosinophil , eicosanoid , g protein coupled receptor , microbiology and biotechnology , biology , pharmacology , g protein , immunology , biochemistry , asthma , arachidonic acid , enzyme
Prostaglandin (PG) D(2) has emerged as a key mediator of allergic inflammatory pathologies and, particularly, PGD(2) induces leukotriene (LT) C(4) secretion from eosinophils. Here, we have characterized how PGD(2) signals to induce LTC(4) synthesis in eosinophils.