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Expression and function of the K + channel KCNQ genes in human arteries
Author(s) -
Ng Fu Liang,
Davis Alison J,
Jepps Thomas A,
Harhun Maksym I,
Yeung Shuk Yin,
Wan Andrew,
Reddy Marcus,
Melville David,
Nardi Antonio,
Khong Teck K,
Greenwood Iain A
Publication year - 2011
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2010.01027.x
Subject(s) - function (biology) , channel (broadcasting) , gene , microbiology and biotechnology , biology , genetics , computer science , telecommunications
KCNQ-encoded voltage-gated potassium channels (K(v) 7) have recently been identified as important anti-constrictor elements in rodent blood vessels but the role of these channels and the effects of their modulation in human arteries remain unknown. Here, we have assessed KCNQ gene expression and function in human arteries ex vivo.