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Dual bronchodilatory and pulmonary anti‐inflammatory activity of RO5024118, a novel agonist at vasoactive intestinal peptide VPAC 2 receptors
Author(s) -
Tannu SA,
Renzetti LM,
Tare N,
Ventre JD,
Lavelle D,
Lin TA,
Morschauser A,
Paciorek J,
Bolin DR,
Michel H,
Singer L,
Hargaden M,
Knowles ID,
Gardiner P,
Cazzola M,
Calzetta L,
Matera MG,
Hicks A.
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2010.00975.x
Subject(s) - bronchoconstriction , agonist , vasoactive intestinal peptide , pharmacology , receptor , medicine , elastase , neutrophil elastase , chemistry , inflammation , neuropeptide , biochemistry , asthma , enzyme
Vasoactive intestinal peptide is expressed in the respiratory tract and induces its effects via its receptors, VPAC(1) and VPAC(2). RO5024118 is a selective VPAC(2) receptor agonist derived via chemical modification of an earlier VPAC(2) agonist, RO0251553. In the present studies, we characterized the pharmacological activity of RO5024118.