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The Electro‐Mechanical window: a risk marker for Torsade de Pointes in a canine model of drug induced arrhythmias
Author(s) -
van der Linde HJ,
Van Deuren B,
Somers Y,
Loenders B,
Towart R,
Gallacher DJ
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2010.00934.x
Subject(s) - medicine , drug , therapeutic window , torsades de pointes , window (computing) , anesthesia , pharmacology , qt interval , computer science , operating system
In cardiovascular pharmacology, electrical and mechanical events can be distinguished, and the phrase 'electro-mechanical window' (EMw) describes the temporal difference between these events. We studied whether changes in EMw have potential predictive value for the occurrence of arrhythmias in fentanyl/etomidate-anaesthetized beagle (FEAB) dogs.