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The PI‐PLC inhibitor U‐73122 is a potent inhibitor of the SERCA pump in smooth muscle
Author(s) -
Hollywood MA,
Sergeant GP,
Thornbury KD,
McHale NG
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2010.00795.x
Subject(s) - phospholipase c , serca , endoplasmic reticulum , inositol , microbiology and biotechnology , biology , atpase , medicine , pharmacology , endocrinology , signal transduction , biochemistry , enzyme , receptor
In this issue MacMillan and McCarron in 2010 demonstrated that the phospholipase C (PLC) inhibitor U-73122 can potently inhibit Ca(2+) release from isolated smooth muscle cells independent of its effect on PLC. Their data suggest that the PLC inhibitor can block the sarcoplasmic/endoplasmic reticulum calcium ATPase pump in smooth muscle and cast doubt on the reliability of U-73122 as the main pharmacological tool to assess the role of the phosphotidyl inositol-PLC pathway in cellular signalling.