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The effects of Δ 9 ‐tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
Author(s) -
Jamontt JM,
Molleman A,
Pertwee RG,
Parsons ME
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2010.00791.x
Subject(s) - cannabidiol , colitis , pharmacology , in vivo , cannabinoid , inflammation , inflammatory bowel disease , chemistry , motility , medicine , immunology , cannabis , receptor , biology , biochemistry , genetics , disease , microbiology and biotechnology , psychiatry
Cannabis is taken as self-medication by patients with inflammatory bowel disease for symptomatic relief. Cannabinoid receptor agonists decrease inflammation in animal models of colitis, but their effects on the disturbed motility is not known. (-)-Cannabidiol (CBD) has been shown to interact with Delta(9)-tetrahydrocannabinol (THC) in behavioural studies, but it remains to be established if these cannabinoids interact in vivo in inflammatory disorders. Therefore the effects of CBD and THC alone and in combination were investigated in a model of colitis.