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Neuroprotective potential of CB 1 receptor agonists in an in vitro model of Huntington's disease
Author(s) -
Scotter EL,
Goodfellow CE,
Graham ES,
Dragunow M,
Glass M
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2010.00773.x
Subject(s) - huntingtin , pertussis toxin , mapk/erk pathway , programmed cell death , microbiology and biotechnology , signal transduction , huntingtin protein , biology , chemistry , apoptosis , mutant , g protein , biochemistry , gene
The therapeutic potential of cannabinoids in Huntington's disease (HD) has been investigated by several groups with complex and sometimes contrasting results. We sought to examine key points of intersection between cannabinoid receptor 1 (CB(1)) signalling, survival and the formation of mutant huntingtin aggregates in HD.