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CB 1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model
Author(s) -
Mukhopadhyay Partha,
Pan Hao,
Rajesh Mohanraj,
Bátkai Sándor,
Patel Vivek,
HarveyWhite Judith,
Mukhopadhyay Bani,
Haskó György,
Gao Bin,
Mackie Ken,
Pacher Pál
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2010.00769.x
Subject(s) - cannabinoid receptor , oxidative stress , inflammation , pharmacology , nitric oxide synthase , programmed cell death , receptor , nitrotyrosine , endocannabinoid system , nephrotoxicity , endocrinology , biology , nitric oxide , chemistry , kidney , medicine , apoptosis , immunology , biochemistry , agonist
Accumulating recent evidence suggests that cannabinoid-1 (CB(1)) receptor activation may promote inflammation and cell death and its pharmacological inhibition is associated with anti-inflammatory and tissue-protective effects in various preclinical disease models, as well as in humans.