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Involvement of 2‐arachidonoyl glycerol in the increased consumption of and preference for ethanol of mice treated with neurotoxic doses of methamphetamine
Author(s) -
GutierrezLopez MD,
Llopis N,
Feng S,
Barrett DA,
O'Shea E,
Colado MI
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2010.00720.x
Subject(s) - am251 , monoacylglycerol lipase , meth , dopaminergic , methamphetamine , endocannabinoid system , chemistry , pharmacology , dopamine , conditioned place preference , dopamine transporter , cannabinoid receptor , cannabinoid , neurotoxicity , amphetamine , medicine , receptor , antagonist , biochemistry , toxicity , monomer , organic chemistry , acrylate , polymer
Methamphetamine (METH) is a psychostimulant amphetamine that causes long-term dopaminergic neurotoxicity in mice. Hypodopaminergic states have been demonstrated to increase voluntary ethanol (EtOH) consumption and preference. In addition, the endocannabinoid system has been demonstrated to modulate EtOH drinking behaviour. Thus, we investigated EtOH consumption in METH-lesioned animals and the role of cannabinoid (CB) signalling in this EtOH drinking.