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Microsomal prostaglandin E synthase‐1 contributes to ischaemic excitotoxicity through prostaglandin E 2 EP 3 receptors
Author(s) -
IkedaMatsuo Y,
Tanji H,
Ota A,
Hirayama Y,
Uematsu S,
Akira S,
Sasaki Y
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2010.00711.x
Subject(s) - excitotoxicity , agonist , prostaglandin e2 receptor , glutamate receptor , receptor , pharmacology , receptor antagonist , medicine , chemistry , endocrinology , biology , antagonist
Although microsomal prostaglandin E synthase (mPGES)-1 is known to contribute to stroke injury, the underlying mechanisms remain poorly understood. This study examines the hypothesis that EP(3) receptors contribute to stroke injury as downstream effectors of mPGES-1 neurotoxicity through Rho kinase activation.