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Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and ‘cannabinoid‐like’ receptors in small arteries
Author(s) -
Daly CJ,
Ross RA,
Whyte J,
Henstridge CM,
Irving AJ,
McGrath JC
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2009.00608.x
Subject(s) - receptor , cannabinoid receptor , ligand (biochemistry) , distribution (mathematics) , chemistry , biophysics , biology , neuroscience , biochemistry , agonist , mathematical analysis , mathematics
Pharmacological analysis of synergism or functional antagonism between different receptors commonly assumes that interacting receptors are located in the same cells. We have now investigated the distribution of alpha-adrenoceptors, beta-adrenoceptors and cannabinoid-like (GPR55) receptors in the mouse arteries.