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Mechanisms of multimodal sensing by extracellular Ca 2+ ‐sensing receptors: a domain‐based survey of requirements for binding and signalling
Author(s) -
Khan Mahvash A,
Conigrave Arthur D
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2009.00603.x
Subject(s) - signalling , extracellular , receptor , calcium sensing receptor , calcium signaling , g protein coupled receptor , microbiology and biotechnology , computational biology , chemistry , calcium , computer science , biology , biochemistry , calcium metabolism , organic chemistry
In this article we consider the molecular basis of sensing and signalling by the extracellular calcium-sensing receptor. We consider the nature of its ligands and sensing modalities, the identities of its major protein domains and their roles in sensing, signalling and trafficking as well as the significance of receptor homo- and hetero-dimerization. Finally, we consider the current, incomplete, state of knowledge regarding the requirements for ligand-specific signalling.