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Stimulation of adenosine A 2B receptors induces interleukin‐6 secretion in cardiac fibroblasts via the PKC‐δ–P38 signalling pathway
Author(s) -
Feng Wei,
Song Yao,
Chen Chao,
Lu Zhi Zhen,
Zhang Youyi
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2009.00558.x
Subject(s) - adenosine , adenosine receptor , protein kinase c , adenosine a3 receptor , medicine , secretion , endocrinology , biology , receptor , signal transduction , cytokine , adenosine a1 receptor , p38 mitogen activated protein kinases , microbiology and biotechnology , mapk/erk pathway , agonist
Inflammatory response and cytokine activation are markedly stimulated after myocardial infarction, and contribute to cardiac remodelling. Interleukin-6 (IL-6), a pro-inflammatory cytokine, has pleiotropic effects on cardiac remodelling. Adenosine, released by all cell types, binds to a class of G protein-coupled receptors to induce various cardiovascular effects. The aim of this work was to investigate whether activation of adenosine receptors, particularly A(2B) adenosine receptors, could stimulate IL-6 secretion in cardiac fibroblasts (CFs).