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Dog left ventricular midmyocardial myocytes for assessment of drug‐induced delayed repolarization: short‐term variability and proarrhythmic potential
Author(s) -
AbiGerges Najah,
Valentin JeanPierre,
Pollard Chris E
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2009.00338.x
Subject(s) - proarrhythmia , dofetilide , afterdepolarization , repolarization , cardiology , medicine , sotalol , torsades de pointes , herg , qt interval , electrophysiology , potassium channel , atrial fibrillation
Evaluation of the potential for delayed ventricular repolarization and proarrhythmia by new drugs is essential. We investigated if dog left ventricular midmyocardial myocytes (LVMMs) that can be used as a preclinical model to assess drug effects on action potential duration (APD) and whether in these cells, short-term variability (STV) or triangulation could predict proarrhythmic potential.