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Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERG‐encoded potassium channel
Author(s) -
Männikkö R,
Overend G,
Perrey C,
Gavaghan CL,
Valentin JP,
Morten J,
Armstrong M,
Pollard CE
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2009.00334.x
Subject(s) - herg , single nucleotide polymorphism , electrophysiology , snp , potassium channel , cls upper limits , potassium channel blocker , chemistry , biology , genetics , biophysics , gene , medicine , genotype , neuroscience , optometry
Potencies of compounds blocking K(V)11.1 [human ether-ago-go-related gene (hERG)] are commonly assessed using cell lines expressing the Caucasian wild-type (WT) variant. Here we tested whether such potencies would be different for hERG single nucleotide polymorphisms (SNPs).