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Molecular and biochemical pharmacology of the histamine H 4 receptor
Author(s) -
Leurs Rob,
Chazot Paul L,
Shenton Fiona C,
Lim Herman D,
De Esch Iwan JP
Publication year - 2009
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2009.00250.x
Subject(s) - histamine h4 receptor , histamine , histamine receptor , receptor , molecular pharmacology , pharmacology , histamine h3 receptor , histamine h2 receptor , immune system , histamine h1 receptor , biology , computational biology , medicine , chemistry , immunology , biochemistry , agonist , antagonist
The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H 4 receptor by several groups has been instrumental for a new appreciation of the role of histamine in the modulation of immune function. In this review, we summarize the historical developments and the molecular and biochemical pharmacology of the H 4 receptor.