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Resolvin D1 controls inflammation initiated by glutathione‐lipid conjugates formed during oxidative stress
Author(s) -
Spite M,
Summers L,
Porter TF,
Srivastava S,
Bhatnagar A,
Serhan CN
Publication year - 2009
Publication title -
british journal of pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2009.00234.x
Subject(s) - oxidative stress , glutathione , inflammation , chemistry , oxidative phosphorylation , biochemistry , pharmacology , medicine , immunology , enzyme
Inflammation is associated with oxidative stress and local generation of lipid peroxidation-derived aldehydes, such as 4-hydroxy-trans-2-nonenal (HNE). In most tissues, HNE is readily conjugated with glutathione and presently it is unknown whether glutathionyl-HNE (GS-HNE) plays a functional role in inflammation. Here, we sought to determine whether GS-HNE is a mediator of oxidative stress-initiated inflammation and if its actions can be regulated by the anti-inflammatory and pro-resolving lipid mediator, resolvin D1 (RvD1).