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Role of G12 proteins in oncogenesis and metastasis
Author(s) -
Juneja Juhi,
Casey Patrick J
Publication year - 2009
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2009.00180.x
Subject(s) - heterotrimeric g protein , biology , effector , g protein , microbiology and biotechnology , signal transduction , gtp binding protein regulators , metastasis , cancer research , cancer , genetics
The G12 subfamily of heterotrimeric guanine nucleotide‐binding proteins consists of two α subunits, Gα12 and Gα13. These proteins mediate signalling via G protein‐coupled receptors and have been implicated in various physiological and pathophysiological processes. A number of direct and indirect effectors of Gα12 and Gα13 have been identified that mediate, or have been proposed to mediate, the diverse cellular responses accompanying activation of G12 proteins. This review describes the signalling pathways and cellular events stimulated by G12 proteins, with a particular emphasis on processes that are important in regulating cell migration and invasion, and could potentially be involved in the pathophysiology of cancer metastasis. Experimental findings directly implicating G12 proteins in the spread of metastatic disease are also summarized, indicating the importance of targeted inhibition of G12 signalling as a potential therapeutic option for locally advanced and metastatic disease.