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Increased endothelin‐1 reactivity and endothelial dysfunction in carotid arteries from rats with hyperhomocysteinemia
Author(s) -
De Andrade CR,
Leite PF,
Montezano AC,
Casolari DA,
Yogi A,
Tostes RC,
Haddad R,
Eberlin MN,
Laurindo FRM,
De Souza HP,
Corrêa FMA,
De Oliveira AM
Publication year - 2009
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2009.00165.x
Subject(s) - endothelin receptor , endocrinology , medicine , endothelium , endothelin 1 , endothelins , receptor , vasodilation , vasoconstriction , endothelial dysfunction , chemistry , biology
There are interactions between endothelin-1 (ET-1) and endothelial vascular injury in hyperhomocysteinemia (HHcy), but the underlying mechanisms are poorly understood. Here we evaluated the effects of HHcy on the endothelin system in rat carotid arteries.