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A role for nitroxyl (HNO) as an endothelium‐derived relaxing and hyperpolarizing factor in resistance arteries
Author(s) -
Andrews Karen L,
Irvine Jennifer C,
Tare Marianne,
Apostolopoulos Jacqueline,
Favaloro Joanne L,
Triggle Chris R,
KempHarper Barbara K
Publication year - 2009
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2009.00150.x
Subject(s) - charybdotoxin , mesenteric arteries , chemistry , hyperpolarization (physics) , apamin , endothelium derived hyperpolarizing factor , myograph , nitroxyl , nitric oxide , acetylcholine , biophysics , vasodilation , endothelium , biochemistry , pharmacology , endocrinology , medicine , membrane potential , potassium channel , stereochemistry , artery , biology , organic chemistry , nuclear magnetic resonance spectroscopy
Nitroxyl (HNO) is emerging as an important regulator of vascular tone as it is potentially produced endogenously and dilates conduit and resistance arteries. This study investigates the contribution of endogenous HNO to endothelium-dependent relaxation and hyperpolarization in resistance arteries.