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AN ANALYSIS OF THE DEPRESSOR RESPONSES TO HISTAMINE IN THE CAT AND DOG: INVOLVEMENT OF BOTH H 1 ‐ AND H 2 ‐RECEPTORS
Author(s) -
BLACK J.W.,
OWEN D.A.A.,
PARSONS M.E.
Publication year - 1997
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1997.tb06827.x
Subject(s) - mepyramine , metiamide , histamine , cats , histamine receptor , histamine h1 receptor , chemistry , endocrinology , receptor , histamine h2 receptor , medicine , pharmacology , anesthesia , antagonist
1 The depressor responses to histamine, in anaesthetized cats and dogs, have been shown to involve both histamine H 1 ‐ and H 2 ‐ receptors. 2 In both species, histamine caused dose‐dependent falls in blood pressure. The dose‐response curve could be displaced to the right by administration of mepyramine 2.5 × 10 −6 mol/kg i.v. The displacement was maximal with a dose‐ratio of less than ten. 3 Metiamide alone, up to 2 × 10 −6 mol kg −1 min −1 , had no significant effect on the histamine dose‐response curve. 4 When administered in the presence of mepyramine, metiamide, 4 × 10 −7 and 2 × 10 −6 mol kg −1 min −1 , caused dose‐dependent displacements to the right, of the histamine dose‐response curve greater than could be achieved with mepyramine alone. 5 The results indicate the presence of both histamine H 1 ‐ and H 2 ‐receptors in the cardiovascular system of the cat and dog. Both receptors produce a common response, i.e. a fall in blood pressure.