Premium
KINETICS OF AGONIST CONDUCTANCE CHANGES DURING HYPERPOLARIZATION AT FROG END PLATES
Author(s) -
ADAMS P.R.
Publication year - 1997
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1997.tb06825.x
Subject(s) - hyperpolarization (physics) , carbachol , acetylcholine , conductance , agonist , chemistry , biophysics , grenouille , endocrinology , medicine , receptor , biology , salientia , biochemistry , stereochemistry , physics , xenopus , condensed matter physics , nuclear magnetic resonance spectroscopy , gene
The effect of rapid hyperpolarization on acetylcholine‐ or carbachol‐induced currents was studied at voltage clamped frog endplates. Following a hyperpolarizing step the agonist‐induced conductance increased approximately exponentially to a new level. The rate constant for this process was smaller during hyperpolarization or lowered temperature, and was also smaller for acetylcholine than for carbachol. The results are interpreted in terms of a potential‐dependent conformational change of the receptor.