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SOME QUANTITATIVE USES OF DRUG ANTAGONISTS
Author(s) -
ARUNLAKSHANA O.,
SCHILD H. O.
Publication year - 1997
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1997.tb06793.x
Subject(s) - atropine , acetylcholine , histamine , pharmacology , antagonism , drug , receptor , histamine receptor , chemistry , biology , antagonist , endocrinology , biochemistry
Various applications of p A x measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law. Examples are given illustrating the use of p A x measurements to identify agonists which act on the same receptors and to compare the receptors of different tissues. Tests of competitive and noncompetitive antagonism are considered in relation to the antagonisms acetylcholine‐atropine, histamine‐atropine and acetylcholine‐cinchonidine. A new measure, p A h , is introduced to express the activity of unsurmountable antagonists.