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Mediation by neurotensin‐receptors of effects of neurotensin on self‐stimulation of the medial prefrontal cortex
Author(s) -
Fernández R.,
Sabater R.,
Sáez J.A.,
Montes R.,
Alba F.,
Ferrer J.M.R.
Publication year - 1996
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1996.tb15985.x
Subject(s) - neurotensin , microinjections , microinjection , stimulation , medicine , endocrinology , receptor , chemistry , prefrontal cortex , neuropeptide , dopamine , neuroscience , psychology , cognition
1 Intracortical microinjections of neurotensin (NT) selectively decreased intracranial self‐stimulation (ICSS) of the medial prefrontal cortex in the rat. 2 To elucidate whether this effect is mediated by NT receptors or by the formation of NT‐dopamine complexes, we investigated the effects on ICSS of intracortical microinjections of neurotensin (1–11), an NT fragment that forms extracellular complexes with dopamine but does not bind to NT receptors. 3 We also studied the effects of the peripheral administration of SR 48692, a selective antagonist of NT receptors, on the inhibition of ICSS produced by the intracortical administration of NT. 4 Unilateral microinjections of neurotensin (1–11) at doses of 10, 20 and 40 nmol into the medial prefrontal cortex did not change the basal ICSS rate of this area. 5 The intraperitoneal administration of SR 48692 at doses of 0.08 and 0.16 mg kg −1 30 min before microinjection of 10 nmol of NT into the medial prefrontal cortex, antagonized the inhibition of ICSS produced by the neuropeptide. 6 These results demonstrate that the inhibitory effect of NT on ICSS is mediated by NT receptors.