Premium
The identification of DL‐ threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal‐regulated kinase signalling in airway smooth muscle
Author(s) -
Tolan Deborah,
Conway AnnMarie,
Steele Leslie,
Pyne Susan,
Pyne Nigel J.
Publication year - 1996
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1996.tb15967.x
Subject(s) - sphingosine , sphingosine kinase , mapk/erk pathway , extracellular , microbiology and biotechnology , kinase , sphingolipid , signal transduction , chemistry , protein kinase a , biology , biochemistry , sphingosine 1 phosphate , receptor
We present entirely novel evidence that DL‐ threo dihydrosphingosine and sphingosine are inhibitors of the extracellular signal‐regulated kinase (ERK) signalling cassette in mammalian cells. We show that DL‐ threo dihydrosphingosine is effective against both growth factor‐ and G‐protein‐dependent activation of ERK. We conclude that DL‐ threo dihydrosphingosine may represent an important pharmacological cell‐permeable agent that may be usefully employed to block smooth muscle cell proliferation.