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The effect of linomide on the migration and the proliferation of capillary endothelial cells elicited by vascular endothelial growth factor
Author(s) -
Parenti Astrid,
Donnini Sandra,
Morbidelli Lucia,
Granger Harris J.,
Ziche Marina
Publication year - 1996
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1996.tb15718.x
Subject(s) - angiogenesis , endothelial stem cell , vascular endothelial growth factor , mechanism of action , vascular endothelial growth factor a , vascular endothelial growth factor c , in vitro , growth factor , vascular endothelial growth factor b , cell growth , endothelium , immunology , vegf receptors , chemistry , medicine , pharmacology , endocrinology , receptor , biochemistry
In order to assess the mechanism of action of the quinoline‐3‐carboxyamide linomide as an antiangiogenic drug, the effect of linomide was studied in vitro on postcapillary endothelial cells exposed to vascular endothelial growth factor (VEGF). Linomide did not block the spontaneous replication of endothelial cells, but significantly suppressed endothelial cell growth and migration elicited by VEGF. It is concluded that linomide appears to be an effective tool to inhibit VEGF‐dependent angiogenesis.