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Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo
Author(s) -
Stanfa L.C.,
Chapman V.,
Kerr N.,
Dickenson A.H.
Publication year - 1996
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1996.tb15618.x
Subject(s) - nociceptin receptor , in vivo , neuroscience , inhibitory postsynaptic potential , dorsum , spinal cord , french horn , chemistry , biology , anatomy , psychology , opioid , opioid peptide , biochemistry , receptor , microbiology and biotechnology , pedagogy
Intrathecally administered nociceptin (5, 50, 225 μg) dose‐relatedly inhibited the C‐fibre evoked wind‐up and post‐discharge of dorsal horn neurones, but not the baseline C‐fibre evoked responses. Spinal naloxone 50 μg, but not 10 μg, reversed the effects of nociceptin. Thus the antinociceptive role of nociceptin in the spinal cord differs from that of classical opioids.