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Endothelin B (ET B ) receptor‐activated potentiation of cholinergic nerve‐mediated contraction in human bronchus
Author(s) -
Fernandes Lynette B.,
Henry Peter J.,
Rigby Paul J.,
Goldie Roy G.
Publication year - 1996
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1996.tb15617.x
Subject(s) - long term potentiation , contraction (grammar) , agonist , cholinergic , endothelin receptor , endocrinology , medicine , stimulation , receptor antagonist , receptor , endothelin 1 , antagonist , muscle contraction , chemistry , biology
In human isolated bronchial preparations, the endothelin B (ET B ) receptor‐selective agonist, sarafotoxin S6c (Stx6c; 1 nM) increased nerve‐mediated contraction in response to electrical field stimulation (EFS) at 0.5‐1 Hz from 19±4% to 42±7% ( n = 9). This effect was blocked in the presence of the ET B receptor‐selective antagonist, BQ‐788 (10 μ m ). These data are consistent with findings in some animal species that ET‐1 and related peptides have marked neuromodulatory influences on the cholinergic system. Furthermore, they provide additional support for the concept that ET‐1 may have a mediator role in bronchial obstruction in asthma.