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Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide
Author(s) -
Giuliani Sandro,
Maggi Carlo Alberto
Publication year - 1996
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1996.tb15576.x
Subject(s) - nociceptin receptor , naltrindole , neurokinin a , endocrinology , (+) naloxone , medicine , opioid , stimulation , chemistry , opioid receptor , opioid peptide , receptor , substance p , neuropeptide
The novel heptadecapeptide opioid, nociceptin, produced a concentration‐dependent (EC 50 28 nM) suppression of the inotropic response of the guinea‐pig isolated renal pelvis to electrical stimulation, a response mediated by release of tachykinins from sensory nerves. Nociceptin did not affect the response to neurokinin A, indicating a prejunctional site of action on tachykininergic nerves. The effect of nociceptin was unchanged in the presence of the μ, δ and *** k opioid receptor antagonists, naloxone, naltrindole and nor‐binaltorphimine.