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Subtypes of losartan‐sensitive angiotensin receptor in the rabbit pulmonary artery
Author(s) -
Sim M.K.,
Chai S.K.
Publication year - 1996
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1996.tb15313.x
Subject(s) - losartan , angiotensin ii receptor type 1 , pulmonary artery , angiotensin ii , medicine , cardiology , pulmonary hypertension , angiotensin receptor , renin–angiotensin system , endocrinology , receptor , blood pressure
1 The short rabbit pulmonary artery was denuded of endothelium and divided into three sections, the cardiac end (cardiac), middle and pulmonary end (pulmonary) sections, respectively. Des‐Asp‐angiotensin I attenuated the contractions of the cardiac and middle sections to transmural nerve stimulation but potentiated the contractions in the pulmonary section. 2 The actions of the nonapeptide were inhibited completely by 10 −6 m losartan; however, a similar concentration of PD123319 had no effect. Indomethacin (10 −6 m ) also inhibited completely the attenuation in the cardiac and middle sections but had no effect on the potentiation seen in the pulmonary section. 3 The data suggest that the two differential responses of the pulmonary artery to des‐Asp‐angiotensin I are mediated by two separate subtypes of the losartan‐sensitive angiotensin AT 1 receptor.