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The dose‐related effects of paracetamol on hyperalgesia and nociception in the rat
Author(s) -
Bianchi M.,
Panerai A.E
Publication year - 1996
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1996.tb15164.x
Subject(s) - nociception , hyperalgesia , anesthesia , medicine , pharmacology , stimulus (psychology) , peripheral , inflammation , psychology , receptor , psychotherapist
1 We have studied the effects of 3 low doses of paracetamol (25, 50 and 100 mg kg −1 p.o.) on inflammatory hyperalgesia, inflammatory oedema, and nociceptive thresholds in rats. 2 At the lower dose (25 mg kg −1 ), paracetamol reduces only central hyperalgesia. 3 At the doses of 50 and 100 mg kg −1 , paracetamol reduces also peripheral hyperalgesia; moreover, it enhances nociceptive thresholds to a mechanical stimulus in the non‐inflamed paws. 4 Neither paw inflammatory oedema nor tail nociceptive thresholds to a thermal stimulus were modified by paracetamol administration. 5 Our results suggest that paracetamol can reduce hyperalgesia without affecting physiological nociception and inflammation.