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Reduction by N G ‐nitro‐L‐arginine methyl ester (L‐NAME) of antigen‐induced nasal airway plasma extravasation in human subjects in vivo
Author(s) -
Dear J.W.,
Scadding G.K.,
Foreman J.C.
Publication year - 1995
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1995.tb16653.x
Subject(s) - extravasation , histamine , nitric oxide , chemistry , albumin , in vivo , antigen , endocrinology , pharmacology , medicine , biochemistry , immunology , microbiology and biotechnology , biology
In non‐allergic subjects, histamine induced a reduction of minimal nasal cross‐sectional area (Amin) and an increase in albumin release into nasal lavage. The effect of histamine on albumin release was inhibited by pretreatment with N G ‐nitro‐L‐arginine methyl ester (L‐NAME), 1 μmol but not by D‐NAME, 1 μmol. L‐NAME, 1 and 10 μmol, did not inhibit the histamine‐induced reduction of Amin. In subjects allergic to grass pollen, antigen challenge induced a reduction in Amin that was not changed by pretreatment with L‐NAME, and an increase in albumin release that was inhibited by L‐NAME, 1 μmol. The data support a role for nitric oxide in mediating plasma extravasation in the nose induced by antigen challenge or histamine.