Premium
Lens opacification by antioestrogens: tamoxifen vs ICI 182, 780
Author(s) -
Zhang Jin Jun,
Jacob Tim J.C.,
Hardy Simon P.,
Higgins Christopher F.,
Valverde Miguel A.
Publication year - 1995
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1995.tb16622.x
Subject(s) - tamoxifen , in vitro , pharmacology , chemistry , lens (geology) , antiestrogen , chloride , nonsteroidal , biology , medicine , biochemistry , cancer , paleontology , organic chemistry , breast cancer
The antioestrogen, tamoxifen, blocks volume‐regulated chloride channels and reduces transparency in bovine lenses maintained in vitro. In contrast to tamoxifen, the sterodial antioestrogen, ICI 182780, did not block volume‐regulated chloride currents in three cultured cell lines and required 10 fold higher concentration to induce significant opacification of bovine lenses maintained in vitro. These data suggest that ocular toxic side effects will be minimized by use of the steroidal (ICI 182780) rather than nonsteroidal antioestrogens (tamoxifen).