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Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardium
Author(s) -
Baxter G.F.,
Goma F.M.,
Yellon D.M.
Publication year - 1995
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1995.tb15866.x
Subject(s) - chelerythrine , cytoprotection , ischemic preconditioning , protein kinase c , medicine , ischemia , cardiology , pharmacology , cardioprotection , coronary occlusion , kinase , chemistry , biochemistry , oxidative stress
Rabbit hearts were preconditioned with four 5 min coronary artery occlusions 24 h before 30 min coronary occlusion with 120 min reperfusion. Preconditioning significantly reduced the percentage of myocardium infarcting within the risk zone from 49.1 ±4.3% to 31.8±3.5% ( P <0.05). When the protein kinase C (PKC) inhibitor, chelerythrine, was administered just before preconditioning, the delayed protection against infarction 24 h later was abolished. We conclude that the delayed cytoprotective response associated with ischaemic preconditioning of myocardium is likely to involve the early activation of one or more PKC subtypes.