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Further evidence of anticonvulsant role for 5‐hydroxytryptamine in genetically epilepsy‐prone rats
Author(s) -
Yan QingShan,
Jobe Phillip C.,
Dailey John W.
Publication year - 1995
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1995.tb15042.x
Subject(s) - epilepsy , anticonvulsant , neuroscience , pharmacology , medicine , biology
1 This study was designed to evaluate further the role of 5‐hydroxytryptamine (5‐HT) in regulating susceptibility and/or intensity of audiogenic seizures in genetically epilepsy‐prone rats. 2 The effects of sertraline, a highly selective and potent inhibitor of 5‐HT uptake, on both the intensity of the audiogenic seizures and the extracellular concentrations of 5‐HT in the thalamus were evaluated in severe seizure genetically epilepsy‐prone rats. 3 Sertraline (7.5, 15 and 30 mg kg −1 , i.p.) produced a dose‐dependent reduction in the intensity of the audiogenic seizures. 4 Brain microdialysis studies showed that the same doses of sertraline also caused dose‐dependent increases in the extracellular 5‐HT concentration in the thalamus of the freely moving rats. 5 The peak anticonvulsant effect correlated temporally with the peak increases in the extracellular 5‐HT concentration for this drug. 6 It is concluded that enhancement of 5‐hydroxytryptaminergic transmission may contribute to the anticonvulsant effect of sertraline in severe seizure genetically epilepsy‐prone rats. 7 The present results coupled with earlier investigations support the hypothesis that 5‐HT plays an anticonvulsant role in genetically epilepsy‐prone rats.