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Nitroglycerin‐induced direct protection of the ischaemic myocardium in isolated working hearts of rats with vascular tolerance to nitroglycerin
Author(s) -
Ferdinandy P.,
Szilvassy Z.,
Csont T.,
Nagy E.,
Dux L.,
Csonka C.,
Koltai M.
Publication year - 1995
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1995.tb15014.x
Subject(s) - nitroglycerin (drug) , medicine , cardiology , ischemia , coronary occlusion , lactate dehydrogenase , coronary circulation , vascular occlusion , anesthesia , blood flow , chemistry , enzyme , biochemistry
We investigated whether nitroglycerin (NTG) was able to produce an anti‐ischaemic effect in isolated working hearts of rats with vascular tolerance to NTG. Hearts isolated from tolerant and non‐tolerant rats were subjected to 10 min coronary occlusion in the presence of 10 −7 m NTG and/or its solvent. NTG alleviated ischaemia‐induced deterioration of cardiac function and decreased lactate dehydrogenase release whilst having no effect on coronary flow nor the area of the ischaemic zone both in hearts isolated from NTG‐tolerant and non‐tolerant rats. The magnitude of the effect was similar in the two groups. These results suggest that the anti‐ischaemic effect of NTG involves direct myocardial mechanisms independent of its vascular action and that vascular tolerance to NTG does not affect this direct protective action.