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Functional evidence for a 5‐HT 2B receptor mediating contraction of longitudinal muscle in human small intestine
Author(s) -
Borman R.A.,
Burleigh D.E.
Publication year - 1995
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1995.tb14935.x
Subject(s) - methysergide , ketanserin , yohimbine , medicine , endocrinology , receptor antagonist , muscle contraction , receptor , 5 ht receptor , contraction (grammar) , ileum , chemistry , biology , antagonist , serotonin
Application of 5‐hydroxytryptamine induces contraction of longitudinal muscle strips from human terminal ileum. The response was resistant to antagonism by ketanserin, ondansetron or DAU6285, but was non‐surmountably antagonized by methysergide. The selective 5‐HT 2B/2C receptor antagonist, SB 200646A evoked a concentration‐dependent, parallel and dextral displacement of the concentration‐response curve to 5‐HT, yielding a pA 2 estimate of 7.17. Application of yohimbine, a 5‐HT 1 and 5‐HT 2B receptor antagonist, also induced a rightward shift of the response curve to 5‐HT, yielding a pA 2 estimate of 8.10. In conclusion, it appears that a 5‐HT 2B receptor mediates the contractile response of the longitudinal muscle of human small intestine to 5‐HT.