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Inhibition by sodium nitroprusside of the expression of inducible nitric oxide synthase in rat neutrophils
Author(s) -
Mariotto S.,
Cuzzolin L.,
Adami A.,
Soldato P.,
Suzuki H.,
Bei G.
Publication year - 1995
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1995.tb13320.x
Subject(s) - sodium nitroprusside , nitric oxide synthase , nitric oxide , chemistry , atp synthase , lipopolysaccharide , enzyme , inhibitory postsynaptic potential , pharmacology , biochemistry , biology , endocrinology , organic chemistry
A well‐known nitric oxide (NO)‐releasing compound, sodium nitroprusside (SNP), decreases in a dose‐dependent manner NO synthase (NOS) activity induced in rat neutrophils by treatment with lipopolysaccharide (LPS). This inhibitory action of SNP seems not to be due to its direct effect on the enzyme activity. The strong nitrosonium ion (NO + ) character of SNP could be responsible for its inhibition of NOS induction in neutrophils.