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Prevention by the tachykinin NK 2 receptor antagonist, SR 48968, of antigen‐induced airway hyperresponsiveness in sensitized guinea‐pigs
Author(s) -
Boichot Elisabeth,
Germain Noella,
Lagente Vincent,
Advenier Charles
Publication year - 1995
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1995.tb13220.x
Subject(s) - bronchoconstriction , ovalbumin , tachykinin receptor , guinea pig , airway hyperresponsiveness , antagonist , endocrinology , medicine , receptor , neurokinin a , immunology , antigen , chemistry , substance p , asthma , neuropeptide
The involvement of tachykinins in antigen‐induced airway hyperresponsiveness (AHR) was characterized pharmacologically in guinea‐pigs sensitized to ovalbumin with antagonists of tachykinin NK 1 and NK 2 receptors, namely SR 140333 and SR 48968, respectively. AHR was illustrated by increased sensitivity to bronchoconstriction provoked by aerosolized acetylcholine in anaesthetized, ventilated animals, administrated 48 h after ovalbumin aerosol challenge. SR 48968 (1 mg kg −1 , i.p.), when given once 30 min before the antigen challenge, prevented AHR, whereas SR 140333 did not. These findings suggest that the tachykinin NK 2 receptor antagonist, SR 48968, may be useful for investigating mechanisms of tachykinins in the development of airway hyperresponsiveness.