Premium
Prevention by dexamethasone of the marked antiarrhythmic effects of preconditioning induced 20 h after rapid cardiac pacing
Author(s) -
Vegh Agnes,
Papp Julius Gy,
Parratt James R.
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb17104.x
Subject(s) - ventricle , medicine , dexamethasone , anesthesia , cardiology , nitric oxide synthase , heart rate , nitric oxide , cardiac pacing , blood pressure
Dogs were paced, via a pacing electrode in the right ventricle, for four 5 min periods at a rate of 220 beats min −1 . On the following day they were reanaesthetized, thoracotomized and the left anterior descending coronary artery occluded for 25 min. Pacing markedly reduced the severity of ischaemia‐induced arrhythmias (e.g. reduction in VF from 45% in unpaced dogs to 10% in paced dogs; P < 0.05), an effect reversed by dexamethasone (4 mg kg −1 i.v., 45 min prior to pacing). This protection may be due to the induction of nitric oxide synthase or cyclo‐oxygenase.