Premium
Activation of BK Ca channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS 1619
Author(s) -
Sellers Andrew J.,
Ashford Michael L.J.
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb17041.x
Subject(s) - iberiotoxin , extracellular , hypothalamus , bk channel , chemistry , endocrinology , biophysics , medicine , conductance , neuroscience , potassium channel , biology , biochemistry , physics , condensed matter physics
NS 1619 activates the large‐conductance Ca 2+ ‐dependent K + channel (BK Ca ) in membrane patches isolated from rat ventromedial hypothalamic neurones. The activation is concentration dependent, with a maximal effect at less than 30 μ m , reversible and can be inhibited by application of iberiotoxin to the extracellular membrane. NS 1619 does not activate ATP‐K + channels present in the same neurones.