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Decrease in calcium currents induced by aminoglycoside antibiotics in frog motor nerve endings
Author(s) -
Redman R.S.,
Silinsky E.M.
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb16998.x
Subject(s) - aminoglycoside , neomycin , acetylcholine , streptomycin , motor nerve , chemistry , free nerve ending , calcium , inhibitory postsynaptic potential , pharmacology , neuroscience , anatomy , anesthesia , biophysics , medicine , biology , antibiotics , biochemistry
1 The effects of the aminoglycoside antibiotics, streptomycin, neomycin and gentamicin were examined on perineural currents and evoked acetylcholine (ACh) release at frog motor nerve endings. 2 In the standard solutions used previously to measure Ca 2+ currents, streptomycin reduced the peak amplitude of the Ca 2+ component of the perineural current. 3 In a solution in which changes in both Ca 2+ currents and evoked ACh release can be recorded simultaneously, both Ca 2+ currents and evoked ACh release were reduced by aminoglycosides in the potency order neomycin > streptomycin > gentamicin. This potency sequence is similar to that reported previously for these agents as inhibitors of neurally‐evoked contractions of mammalian skeletal muscle. 4 These data suggest that the presynaptic inhibitory effects of aminoglycoside antibiotics at the neuromuscular junction occur as a consequence of a reduction in Ca 2+ currents in the motor nerve terminal.