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Diosmin‐induced increase in sensitivity to Ca 2+ of the smooth muscle contractile apparatus in the rat isolated femoral vein
Author(s) -
Savineau JeanPierre,
Marthan Roger
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb14838.x
Subject(s) - diosmin , chemistry , vein , vasomotor , femoral vein , anatomy , biophysics , medicine , endocrinology , biochemistry , biology , flavonoid , antioxidant
The effect of diosmin, a flavone derivative, on the Ca 2+ sensitivity of the venous contractile apparatus was investigated in chemically (β‐escin) skinned strips from the rat isolated femoral vein. Diosmin (0.5–10 μ m ) shifted to the left the concentration‐response curve to Ca 2+ (0.05–5 μ m ). The maximal effect was observed in the presence of 1 μ m diosmin which increased the contractile response evoked by 0.15 μ m Ca 2+ from 26.3% to 78.9% of the maximal Ca 2+ ‐induced response. This work demonstrates that the venotonic action of diosmin involves an increase in the Ca 2+ sensitivity of the contractile apparatus. Such a mechanism of action could represent a new and important means of therapeutic control of vasomotor activity.