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Reduction by Hoe 140, the B 2 kinin receptor antagonist, of antigen‐induced nasal blockage
Author(s) -
Austin C.E.,
Foreman J.C.,
Scadding G.K.
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb14835.x
Subject(s) - kinin , nasal administration , bradykinin , antagonist , receptor , house dust mite , receptor antagonist , antigen , immunology , medicine , nasal provocation test , endocrinology , vascular permeability , pharmacology , chemistry , allergy , allergen
In subjects with allergic rhinitis to house‐dust mite (HDM), antigen challenge produced a significant increase in nasal blockage but had no effect on nasal vascular permeability. The B 2 kinin receptor antagonist, [ d ‐Arg 0 , Hyp 3 , Thi 5 , d ‐Tic 7 , Oic 8 ]‐bradykinin (Hoe 140), 200 μg administered by intranasal aerosol 2 min prior to challenge with HDM, 500 u significantly reduced nasal blockage induced by the antigen challenge. The data are compatible with a role for B 2 kinin receptors in the nasal response to challenge with antigen which is responsible for nasal blockage.