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Antidepressant‐like effects of CCK B antagonists in mice: antagonism by naltrindole
Author(s) -
Derrien M.,
Durieux C.,
Roques B.P.
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb14832.x
Subject(s) - naltrindole , antagonism , antagonist , pharmacology , stimulation , chemistry , receptor , opioid , endocrinology , naltrexone , opioid receptor , medicine , biology , biochemistry
1 The effects of selective CCK B agonists, BC 264 and BC 197 were investigated in the conditioned suppression of motility test in mice, an animal model used to select antidepressant drugs. The results showed that both CCK B agonists at doses of 3 and 30 μg kg −1 , accentuated the suppression of motility in shocked mice and did not modify the behaviour of non‐shocked mice. The effects of BC 264 were suppressed by L‐365,260. 2 L‐365,260 alone, at doses of 0.2 and 2 mg kg −1 decreased motor inhibition in shocked mice and had no effect in non‐shocked mice. 3 The effects of L‐365,260 observed in shocked mice were suppressed by naltrindole, a selective antagonist for δ‐opioid receptors, suggesting the occurrence of physiological adverse interactions between CCK and opioid systems. 4 Together, these results suggest that CCK B antagonists could block centrally located CCK B receptors to produce antidepressant‐like effects which could indirectly involve δ‐opioid receptor stimulation.