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Pharmacokinetics, plasma protein binding and urinary excretion of N ω ‐nitro‐L‐arginine in rats
Author(s) -
TabriziFard Mohammad A.,
Fung HoLeung
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb14747.x
Subject(s) - pharmacokinetics , excretion , arginine , endocrinology , urinary system , medicine , chemistry , plasma protein binding , pharmacology , biochemistry , amino acid
The in vivo disposition of N ω ‐nitro‐ l ‐arginine ( l ‐NOARG) has been examined in rats. Plasma concentrations of l ‐NOARG following an intravenous dose of 10 mg kg −1 were determined by high‐performance liquid chromatography. Plasma l ‐NOARG concentrations declined biexponentially, with average half‐lives of 11 min and 20 h. l ‐NOARG clearance did not appear to exhibit concentration‐dependency below a plasma concentration of 4.56 × 10 −4 m (100 mg 1 −1 ). Ultrafiltration studies revealed insignificant binding of l ‐NOARG to rat plasma proteins. Urinary excretion of unchanged l ‐NOARG was minimal. These pharmacokinetic information may be useful in the design of in vivo experiments involving l ‐NOARG, as well as in the interpretation of the pharmacodynamics of this important nitric oxide synthase inhibitor.