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Natriuretic action of angiotensin(1–7)
Author(s) -
DelliPizzi AnnMarie,
Hilchey Sean D.,
BellQuilley Caroline P.
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb14014.x
Subject(s) - natriuresis , diuresis , endocrinology , medicine , renin–angiotensin system , kidney , angiotensin ii , renal function , sodium , chemistry , blood pressure , organic chemistry
Evidence that angiotensin (1–7) (Ang(1–7)) is biologically active and can be synthesized by the kidney prompted us to examine its actions in the rat, isolated kidney. Ang(1–7) had three major effects producing, (1) a substantial natriuresis and diuresis, (2) an increase in urinary sodium concentration associated with a fall in potassium concentration and (3) an increase in glomerular filtration rate without affecting renal vascular resistance. Thus, Ang(1–7) may participate in the renal effects of the renin‐angiotensin system.